Scientific studies on Tongkat Ali

Scientific studies on Tongkat Ali

Eurycoma longifolia Jack, locally known as Tongkat ali, is a common shrub found along the slopes in hilly terrains of the Malaysian rainforest.  A water decoction of the root of Tongkat ali is a well-known traditional supplement for the enhancement of sexuality and fertility and is also used as an anti-aging tonic. This aqueous extract contains, among other things, tannins, high-molecular-weight polysaccharides, glycoprotein, mucopolysaccharides and quassinoid alkaloids, which exhibit anti-malarial, anti-ulcer, anti-tumor, antiparasitic and anti-pyretic activities.

These research papers are among many other scientific research carried out regarding Tongkat Ali. These provide unbiased scientific evidence on Tongkat Ali.

  1. Genuine Tongkat Ali root extract can substantially increase muscle strength, testosterone level, burn excess fat, promote muscle building and many more other benefits.

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  1. Recent human trials have proven its testosterone-enhancing and anti-stress or anti-aging effects, which are accompanied or mediated, respectively, by normalized serum growth hormone concentrations and elevated concentrations of superoxide dismutase (SOD), an important anti-oxidant. A standardized extract of the Tongkat Ali aka Eurycoma longifolia Jack root may prove useful in treating men with idiopathic infertility.
  2. After it had been established that tongkat ali increases the body’s own synthesis of testosterone, it was suggested that tongkat ali is used instead of testosterone replacement therapy in older men with declined levels of hormone.

4. The effects of tongkat ali extract of various dosages on sperm quality was tested. It was established that tongkat ali extract can help with sperm motility and other parameters.

5. The aromatase conversion of testosterone into estrogens is of great concern to bodybuilders as it can lead to gynecomastia and reduce the muscle-building effect of testosterone. The eurycomanone of tongkat ali is an effective aromatase inhibitor. This has resulted in the distribution of numerous fake tongkat ali products claiming high eurycomanone content. Tongkat ali buyers are advised to tread carefully when shopping for tongkat ali. Offers that are too good to be true, inevitably aren’t.


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  • Bano F, Singh RK, Singh R, Siddiqui MS, Mahdi AA. Seminal plasma lipid peroxide levels in infertile men.  J Endocrinol Reprod 1999; 3: 20–8.
  • Sikka SC. Relative impact of oxidative stress on male reproductive function.  Curr Med Chem 2001; 8: 851–62.
  • Burkill IH, Hanif M. Malay village medicine, prescriptions collected. Gardens Bulletin Strait Settlements 1930; 6: 176–7.
  • Ali JM, Saad JM. Biochemical effect of Eurycoma Longifolia Jack on the sexual behavior, fertility, sex hor mone and glycolysis [Dissertation]. Department of Biochemistry, University of Malaya.
  • Ang HH, Sim MK. Eurycoma longifolia increases sexual motivation in sexually naive male rats. Arch Pharm Res 1998; 21: 779–81.
  • Ang HH, Sim MK. Eurycoma longifolia Jack and orientation activities in sexually experienced male rats. Biol Pharm Bull 1998; 21: 153–5.
  • Ang HH, Sim MK. Eurycoma Longifolia Jack increases sexual motivation in sexually naive male rats.  Archives of Pharmacal Research 1998; 21: 778–81.
  • Kuo PC, Damu AG, Lee KH, Wu TS. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem 2004; 12: 537–44.
  • Jiwajinda S, Santisopasri V, Murakami A, Sugiyama H, Gasquet M, et al. In vitro anti-tumor promoting and antiparasitic activities of the quassinoids from Eurycoma longifolia, a medicinal plant in Southeast Asia. J Ethnopharmacol 2002; 82: 55–8.
  • Hamzah S, Yusof A. The ergogenic effects of Tongkat Ali (Eurycoma Longifolia). Br J Sports Med 2003; 37: 465–66.
  • Asiah O, Nurhanan MY, Ilham MA. Determination of bioactive peptide (4.3 kDa) as an aphrodisiac marker in six Malaysia plants.  J Tropical Forest Sci 2007; 19:  61–3.
  • Sambandan TG, Rha C, Kadir AA, Aminudim N, Saad JM. Bioactive fraction of Eurycoma longifolia. US Patent: US7, 132,117 B2 2006.
  • Tambi MI. Glycoprotein water-soluble extract of Eurycoma Longifolia Jack as a health supplement in management of Health aging in aged men. In: Lunenfeld B, editor. Abstracts of the 3rd World Congress on the Aging Male, February 7–10, 2002, Berlin, Germany.  Aging Male 2002; 6. [Abstract].
  • Tambi MI. Water soluble Extract of Eurycoma Longifolia in enhancing testosterone in males. In: Proceeding of International Trade Show and Conference, Supply Side West, The Venetian, Las Vegas, Nevada, USA. 2003 Oct 1–3.
  • Tambi MI. Standardized water soluble extract of Eurycoma Longifolia (LJ100) on men’s health.  In: Abstracts of the 8th International Congress of Andrology, 12–16 June 2005, Seoul, Korea. Int J Androl 2005; 28 (Suppl 1): 27.
  • Tambi MI. Standardized water soluble extract of Eurycoma Longifolia LJ100 maintains healthy aging in man.  In: Lunenfeld B, editor. Abstracts of the 5th World Congress on the Aging Male. February 9-12, 2006, Salzburg, Austria. Aging Male 2006; 9. [Abstract]
  • Tambi MI. Eurycoma Longifolia jack: a potent adaptogen in the form of water-soluble extract with the effect of maintaining men’s health.  Asian J Androl 2006; 8 (Suppl 1): 49–50.
  • World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Sperm–Cervical Mucus Interaction. New York: Cambridge University Press; 1999.
  • Lenzi A, Picardo M, Gandini L, Dondero F. Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.  Hum Reprod Update 1996; 2: 246–56.
  • Lenzi A, Lombardo F, Sgro P, Salacone P, Caponecchia L, et al. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertil Steril 2003; 79: 292–300.
  • Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility.  Int J Urol 2009; 16: 449–57.
  • Kruger TF, Coetzee K. The role of sperm morphology in assisted reproduction.  Hum Reprod Update 1999; 5: 172–8.
  • Burr RW, Siegberg R, Flaherty SP, Wang XJ, Matthews CD. The influence of sperm morphology and the number of motile sperm inseminated on the outcome of intrauterine insemination combined with mild ovarian stimulation.  Fertil Steril 1996; 65: 127–32.
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